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dc.contributorQuaranto, Chelseaen_US
dc.contributor.editorBartlett, Zane N.en_US
dc.creatorHaskett, Dorothy R.en_US
dc.date.accessioned2015-07-30T08:31:38Z
dc.date.available2015-07-30T08:31:38Z
dc.date.created2015-07-30en_US
dc.date.issued2015-07-30
dc.identifier.urihttp://hdl.handle.net/10776/8685
dc.description.abstractThe hedgehog signaling pathway is a mechanism that directs the development of embryonic cells in animals, from invertebrates to vertebrates. The hedgehog signaling pathway is a system of genes and gene products, mostly proteins, that convert one kind of signal into another, called transduction. In 1980, Christiane Nusslein-Volhard and Eric F. Wieschaus, at the European Molecular Biology Laboratory in Heidelberg, Germany, identified several fruit fly (Drosophila melanogaster) genes. They found that when those genes were changed or mutated, the mutated genes disrupted the normal development of fruit fly larvae. The researchers called one of the genes hedgehog (abbreviated hh). Nusslein-Volhard, Wieschaus, and Edward B. Lewis, at the California Institute of Technology in Pasadena, California, shared the 1995 Nobel Prize for Physiology or Medicine for their research on how genes control early embryonic development in fruit flies. The hedgehog signaling pathway is conserved across many animal taxa or phyla, from Drosophila to humans. The hedgehog signaling pathway controls several key components of embryonic development, stem-cell maintenance, and it influences the development of some cancers.en_US
dc.format.mediumtext/xhtmlen_US
dc.language.isoengen_US
dc.publisherArizona State University. School of Life Sciences. Center for Biology and Society. Embryo Project Encyclopedia.en_US
dc.relation.ispartofEmbryo Project Encyclopediaen_US
dc.rightsCopyright Arizona Board of Regentsen_US
dc.subjectConcepten_US
dc.subject.lcshEmbryologyen_US
dc.subject.lcshEmbryosen_US
dc.subject.lcshNüsslein-Volhard, C. (Christiane)en_US
dc.subject.lcshWieschaus, Eric F.en_US
dc.subject.lcshEuropean Molecular Biology Laboratoryen_US
dc.subject.lcshCellular signal transductionen_US
dc.subject.lcshEmbryological developmenten_US
dc.subject.lcshDrosophila melanogasteren_US
dc.subject.lcshFruit-fliesen_US
dc.subject.lcshLewis, Edward B., 1918-2004en_US
dc.subject.lcshNobel Prize winnersen_US
dc.subject.lcshVertebratesen_US
dc.subject.lcshIngham, Phil W.en_US
dc.subject.lcshGenesen_US
dc.subject.lcshHomeobox genesen_US
dc.subject.meshHedgehog Proteinsen_US
dc.titleHedgehog Signaling Pathwayen_US
dc.typeTexten_US
dc.rights.licenseLicensed as Creative Commons Attribution-NonCommercial-Share Alike 3.0 Unported (CC BY-NC-SA 3.0) http://creativecommons.org/licenses/by-nc-sa/3.0/en_US
dc.subject.embryoProcessesen_US
dc.subject.tagHedgehogen_US
dc.subject.taghhen_US
dc.subject.tagsignaling pathwayen_US
dc.description.typeArticlesen_US
dc.date.createdstandard2015-07-30en_US


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