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dc.contributor.editorTurriziani Colonna, Federicaen_US
dc.creatorBartlett, Zaneen_US
dc.date.accessioned2014-11-14T23:18:32Z
dc.date.available2014-11-14T23:18:32Z
dc.date.created2014-11-14en_US
dc.date.issued2014-11-14
dc.identifier.urihttp://hdl.handle.net/10776/8237
dc.description.abstractThe Hayflick Limit is a concept that helps to explain the mechanisms behind cellular aging. The concept states that a normal human cell can only replicate and divide forty to sixty times before it cannot divide anymore, and will break down by programmed cell death or apoptosis. The concept of the Hayflick Limit revised Alexis Carrel's earlier theory, which stated that cells can replicate themselves infinitely. Leonard Hayflick developed the concept while at the Wistar Institute in Philadelphia, Pennsylvania, in 1965. In his 1974 book Intrinsic Mutagenesis, Frank Macfarlane Burnet named the concept after Hayflick. The concept of the Hayflick Limit helped scientists study the effects of cellular aging on human populations from embryonic development to death, including the discovery of the effects of shortening repetitive sequences of DNA, called telomeres, on the ends of chromosomes. Elizabeth Blackburn, Jack Szostak and Carol Greider received the Nobel Prize in Physiology or Medicine in 2009 for their work on genetic structures related to the Hayflick Limit.en_US
dc.format.mediumtext/xhtmlen_US
dc.language.isoengen_US
dc.publisherArizona State University. School of Life Sciences. Center for Biology and Society. Embryo Project Encyclopedia.en_US
dc.relation.ispartofEmbryo Project Encyclopediaen_US
dc.rightsCopyright Arizona Board of Regentsen_US
dc.subjectConcepten_US
dc.subject.lcshHayflick, Leonarden_US
dc.subject.lcshCellsen_US
dc.subject.lcshCell populationsen_US
dc.subject.lcshCell deathen_US
dc.subject.lcshApoptosisen_US
dc.subject.lcshCell proliferationen_US
dc.subject.lcshCell cycleen_US
dc.subject.lcshCarrel, Alexis, 1873-1944en_US
dc.subject.lcshAgingen_US
dc.subject.lcshWistar Institute of Anatomy and Biologyen_US
dc.subject.lcshTelomereen_US
dc.subject.lcshChromosomesen_US
dc.subject.lcshTelomeraseen_US
dc.subject.lcshGreider, Carol W.en_US
dc.subject.lcshBlackburn, Elizabeth H.en_US
dc.titleThe Hayflick Limiten_US
dc.typeTexten_US
dc.rights.licenseLicensed as Creative Commons Attribution-NonCommercial-Share Alike 3.0 Unported (CC BY-NC-SA 3.0) http://creativecommons.org/licenses/by-nc-sa/3.0/en_US
dc.subject.embryoTheoriesen_US
dc.subject.tagAlexey Olovnikoven_US
dc.description.typeArticlesen_US


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