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dc.contributor.editorHaskett, Dorothy Reganen_US
dc.creatorBartlett, Zaneen_US
dc.date.accessioned2014-08-19T22:32:57Z
dc.date.available2014-08-19T22:32:57Z
dc.date.created2014-08-19en_US
dc.date.issued2014-08-19
dc.identifier.urihttp://hdl.handle.net/10776/8150
dc.description.abstractIn the 1990s, researchers working at the Roslin Institute in Edinburgh, Scotland, performed cloning experiments in collaboration with PPL Therapeutics in Roslin, Scotland, on human coagulation factor IX, a protein. The team of scientists used the methods identified during the Dolly experiments to produce transgenic livestock capable of producing milk containing human blood clotting factor IX, which helps to treat a type of hemophilia. By using a cell's resting state, called quiescence, or G0, and transferring modified nuclear material from one cell to an egg cell that had had its nuclear material removed, the researchers developed a method to produce genetically modified mammals, including humans. Angelika E. Schnieke, Alexander J. Kind, William A. Ritchie, Karen Mycock, Angela R. Scott, Marjorie Ritchie, Ian Wilmut, Alan Colman, and Keith H. S. Campbell published the results of their experiments as Human Factor IX Transgenic Sheep Produced by Transfer of Nuclei from Transfected Fetal Fibroblasts (hereafter called Human Factor IX). The article details the methods that produced the cloned sheep named Polly, as well as other cloned and genetically altered sheep.en_US
dc.format.mediumtext/xhtmlen_US
dc.language.isoengen_US
dc.publisherArizona State University. School of Life Sciences. Center for Biology and Society. Embryo Project Encyclopedia.en_US
dc.relation.ispartofEmbryo Project Encyclopediaen_US
dc.rightsCopyright Arizona Board of Regentsen_US
dc.subjectExperimenten_US
dc.subject.lcshCloningen_US
dc.subject.lcshChristmas factoren_US
dc.subject.lcshFactor IX (Blood coagulation)en_US
dc.subject.lcshRoslin Instituteen_US
dc.subject.lcshWilmut, Ianen_US
dc.subject.lcshCampbell, Keith, 1954-2012en_US
dc.subject.meshCloning, Molecularen_US
dc.subject.meshNuclear Transfer Techniquesen_US
dc.subject.meshGenetic Engineeringen_US
dc.subject.meshPolly the Sheepen_US
dc.title"Human Factor IX Transgenic Sheep Produced by Transfer of Nuclei from Transfected Fetal Fibroblasts" (1997), by Angelika E. Schnieke, et al.en_US
dc.typeTexten_US
dc.rights.licenseLicensed as Creative Commons Attribution-NonCommercial-Share Alike 3.0 Unported (CC BY-NC-SA 3.0) http://creativecommons.org/licenses/by-nc-sa/3.0/en_US
dc.subject.embryoExperimentsen_US
dc.description.typeArticlesen_US


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