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dc.contributor.editorBartlett, Zane N.en_US
dc.creatorHaskett, Dorothy R.en_US
dc.date.accessioned2014-07-12T00:33:01Z
dc.date.available2014-07-12T00:33:01Z
dc.date.created2014-07-11en_US
dc.date.issued2014-07-11
dc.identifier.urihttp://hdl.handle.net/10776/8031
dc.description.abstractMitochondrial diseases in humans result when the small organelles called mitochondria, which exist in all human cells, fail to function normally. The mitochondria contain their own mitochondrial DNA (mtDNA) separate from the cell's nuclear DNA (nDNA). The main function of mitochondria is to produce energy for the cell. They also function in a diverse set of mechanisms such as calcium hemostasis, cell signaling, regulation of programmed cell death (apoptosis), and biosynthesis of heme proteins that carry oxygen. When mitochondria fail to fulfill those functions properly in the cell, many different maladies, including death, can occur. Humans inherit mitochondria from the mother through the egg cell, and all the mtDNA molecules in a person are identical to each other. But the mutation rate is much higher in the mtDNA than in nuclear DNA, and some individuals may have more than one type of mtDNA. As egg cells develop, they divide via a process called meiosis. As egg cells divide, mitochondria of different types can randomly segregate in some new cells but not in others. As a result, two offspring from the same female might differ in their types of mitochondria. Random amounts of the two mitochondria types can lead to some offspring inheriting a mitochondrial disease or developmental abnormalities while others are normal.en_US
dc.format.mediumtext/xhtmlen_US
dc.language.isoengen_US
dc.publisherArizona State University. School of Life Sciences. Center for Biology and Society. Embryo Project Encyclopedia.en_US
dc.relation.ispartofEmbryo Project Encyclopediaen_US
dc.rightsCopyright Arizona Board of Regentsen_US
dc.subjectConcepten_US
dc.subject.lcshMitochondrial pathologyen_US
dc.subject.lcshMitochondriaen_US
dc.subject.lcshCell organellesen_US
dc.subject.lcshNuclear transferen_US
dc.subject.lcshReproductive technologyen_US
dc.subject.meshMitochondrial Diseasesen_US
dc.titleMitochondrial Diseases in Humansen_US
dc.typeTexten_US
dc.rights.licenseLicensed as Creative Commons Attribution-NonCommercial-Share Alike 3.0 Unported (CC BY-NC-SA 3.0) http://creativecommons.org/licenses/by-nc-sa/3.0/en_US
dc.subject.embryoDisordersen_US
dc.subject.embryoReproductionen_US
dc.subject.tagpronuclear transferen_US
dc.subject.tagmaternal spindle transferen_US
dc.subject.tagLuft's Diseaseen_US
dc.description.typeArticlesen_US


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