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dc.contributor.editorO'Brien, Cearaen_US
dc.creatorCox, Troyen_US
dc.date.accessioned2014-01-14T18:23:16Z
dc.date.available2014-01-14T18:23:16Z
dc.date.created2014-01-10en_US
dc.date.issued2014-01-14
dc.identifier.urihttp://hdl.handle.net/10776/7357
dc.description.abstractIn the late 1980s, Peter Goodfellow in London, UK led a team of researchers who showed that the SRY gene in humans codes a protein that causes testes to develop in embryos. During this time, scientists in London and Paris, including Peter Koompan and John Gubbay, proposed that SRY was the gene on the Y chromosome responsible for encoding the testis-determining factor (TDF) protein. The TDF is a protein that initiates embryo to develop male characteristics. Looking for evidence that SRY was the TDF, Goodfellow and colleagues examined people who were anatomically female, but whose cells had Y chromosomes. Females normally have cells with two X sex chromosomes (XX), while males normally have cells with one X and one Y chromosome (XY). Goodfellow's team discovered that individuals with Y chromosomes developed as female instead of as male due to inactive SRY sequences on the Y chromosome. Goodfellow and colleagues compiled the results of their experiment in a paper titled Genetic Evidence Equating SRY and the Testis-Determining Factor in 1990. Their results showed that the SRY gene is necessary for male characteristics to develop in embryos, and that SRY encodes the TDF protein.en_US
dc.format.mediumtext/xhtmlen_US
dc.language.isoengen_US
dc.publisherArizona State University. School of Life Sciences. Center for Biology and Society. Embryo Project Encyclopedia.en_US
dc.relation.ispartofEmbryo Project Encyclopediaen_US
dc.rightsCopyright Arizona Board of Regentsen_US
dc.subjectExperimenten_US
dc.subject.lcshTestisen_US
dc.subject.lcshY chromosome
dc.subject.lcshembryos
dc.subject.lcshChromosomes
dc.subject.lcshSex chromosomes
dc.subject.lcshSex determination, Genetic
dc.subject.lcshSex differentiation
dc.subject.lcshHuman chromosomes
dc.subject.lcshKoopman, Peter
dc.subject.meshGenes, sryen_US
dc.subject.meshSex-Determining Region Y Proteinen_US
dc.subject.meshY Chromosomeen_US
dc.title"Genetic Evidence Equating SRY and the Testis-Determining Factor" (1990), by Phillippe Berta et al.en_US
dc.typeTexten_US
dc.rights.licenseLicensed as Creative Commons Attribution-NonCommercial-Share Alike 3.0 Unported (CC BY-NC-SA 3.0) http://creativecommons.org/licenses/by-nc-sa/3.0/en_US
dc.subject.embryoExperimentsen_US
dc.subject.tagsex-related gene On Yen_US
dc.subject.tagsex determination processesen_US
dc.subject.tagtestis-determining factoren_US
dc.description.typeArticlesen_US


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