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dc.creatorPhilbrick, Samuelen_US
dc.date.accessioned2012-05-25T15:48:23Z
dc.date.available2012-05-25T15:48:23Z
dc.date.created2010-11-20en_US
dc.date.issued2012-05-25
dc.identifier.otherembryo:128551en_US
dc.identifier.urihttp://hdl.handle.net/10776/2309
dc.description.abstractIn November 2007, Masato Nakagawa, along with a number of other researchers including Kazutoshi Takahashi, Keisuke Okita, and Shinya Yamanaka, published "Generation of Induced Pluripotent Stem Cells without Myc from Mouse and Human Fibroblasts" (abbreviated "Generation") in Nature. In "Generation," the authors point to dedifferentiation of somatic cells as an avenue for generating pluripotent stem cells useful for treating specific patients and diseases. They provide background to their research by observing that previous attempts to reprogram somatic cells to a state of greater differentiability with retroviral factors Oct3/4, Sox2, c-Myc, and Klf4 had succeeded in producing induced pluripotent stem (iPS) cells that contributed to viable adult chimeras and possessed germline competency. However, as they note, the c-Myc retrovirus contributes to tumors in generated chimeras, rendering iPS cells produced with c-Myc useless for clinical applications. The authors attempt to overcome this problem by modifying the standard protocol for producing iPS cells in mice in such a way that the c-Myc retrovirus is removed. They identify problems and benefits associated with this method, but most importantly note that their method generated iPS cells that did not cause tumors in chimeric mice. Nakagawa and colleagues also report that they successfully reprogrammed adult dermal fibroblasts to return to a pluripotent state without c-Myc.en_US
dc.format.mediumtext/xhtmlen_US
dc.language.isoengen_US
dc.publisherArizona State University. School of Life Sciences. Center for Biology and Society. Embryo Project Encyclopedia.en_US
dc.relation.ispartofEmbryo Project Encyclopediaen_US
dc.rightsen_US
dc.rights© Arizona Board of Regentsen_US
dc.subjectLiteratureen_US
dc.subject.meshStem Cellsen_US
dc.title"Generation of Induced Pluripotent Stem Cells without Myc from Mouse and Human Fibroblasts" (2007), by Masato Nakagawa et al.en_US
dc.typeTexten_US
dc.rights.licenseLicensed as Creative Commons Attribution-NonCommercial-Share Alike 3.0 Unported (CC BY-NC-SA 3.0) http://creativecommons.org/licenses/by-nc-sa/3.0/
dc.subject.embryoPublicationsen_US
dc.subject.embryoExperimentsen_US
dc.subject.tagMiceen_US
dc.subject.tagChimerasen_US
dc.subject.tagStem cellsen_US
dc.subject.tagPluripotencyen_US
dc.description.typeArticlesen_US
dc.date.createdstandard2010-11-20


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