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dc.contributor.editorGuerrero, Annaen_US
dc.creatorHowell-Moroney, Madeleine
dc.date2022-01-14en_US
dc.date.accessioned2022-01-27T16:13:01Z
dc.date.available2022-01-27T16:13:01Z
dc.date.created2022-01-27
dc.identifier.urihttps://hpsrepository.asu.edu/handle/10776/13328
dc.descriptionThe CRISPR-cas9 system is a way for bacteria to eliminate bacteriophages, or viruses that infect bacteria. In this image, the CRISPR-cas9 system of the bacteria Streptococcus thermophilus is shown. First, a virus with an unknown genome, shown in blue, attacks the cell. Part of the viral genome is copied and used to create a new spacer. The spacer is inserted between repeating CRISPR sequences in the bacterial genome. Then, the bacterium is attacked by a virus that has attacked before, shown in orange. The bacterium’s CRISPR/cas-9 system recognizes the virus, and the corresponding spacer matches up to the target sequence in the viral genome. Using the target sequence, the cas-9 protein guides a CRISPR-RNA with the spacer to deactivate the viral genome at the target sequence.en_US
dc.format.mediumpng/tiffen_US
dc.language.isoen_USen_US
dc.language.isoen_USen_US
dc.publisherArizona State University. School of Life Sciences. Center for Biology and Society. Embryo Project Encyclopedia.en_US
dc.relation.ispartofEmbryo Project Encyclopediaen_US
dc.rightsCopyright Arizona Board of Regentsen_US
dc.subjectExperimentsen_US
dc.subject.lcshCRISPR-associated protein 9en_US
dc.subject.lcshCas9 (CRISPR-associated protein 9)en_US
dc.subject.lcshCas9 (CRISPR-associated protein 9)en_US
dc.subject.lcshCRISPR/Cas9en_US
dc.subject.meshCas9 Endonucleaseen_US
dc.subject.meshCas9 Enzymeen_US
dc.subject.meshCas9 Proteinen_US
dc.titleCRISPR-cas9en_US
dc.typeImageen_US
dc.rights.licenseLicensed as Creative Commons Attribution-NonCommercial-Share Alike 3.0 Unported (CC BY-NC-SA 3.0) http://creativecommons.org/licenses/by-nc-sa/3.0en_US
dc.subject.embryoExperimentsen_US
dc.subject.tagCas 9en_US
dc.subject.tagCRISPRen_US
dc.description.typeGraphicsen_US
dc.relation.referencesCong, Le, F. Ann Ran, David Cox, Shuailiang Lin, Robert Barretto, Naomi Habib, Patrick Hsu, Xuebing Wu Wenyan Jiang, Luciano Marraffini, and Feng Zhang. Multiplex Genome Engineering Using CRISPR/Cas Systems. Science 339 (2013): 819–23. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3795411/ (Accessed July 30, 2019).en_US
dc.relation.referencesIshino, Yoshizumi, Hideo Shinagawa, Kozo Makino, Mitsuko Amemura, and Atsuo Nakata. Nucleotide Sequence of the iap Gene, Responsible for Alkaline Phosphatase Isozyme Conversion in Escherichia coli, and Identification of the Gene Product. Journal of Bacteriology 169 (1987): 5429– 33. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC213968/pdf/jbacter00202-0107.pdf (Accessed July 30, 2019).en_US
dc.relation.referencesJinek, Martin, Krzysztof Chylinski, Ines Fonfara, Michael Hauer, Jennifer Doudna, and Emmanuelle Charpentier. A Programmable Dual-RNA-Guided DNA Endonuclease in Adaptive Bacterial Immunity. Science 337 (2012): 816–21.en_US
dc.description.procedureGraphic was made with a Wacom Intuos 5 pen and tablet. Made in programs of Adobe Creative Suite, Illustrator, Photoshop, and Acrobat Pro.en_US


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