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dc.contributor.editorGleason, Kevin M.en_US
dc.creatorZhu, Meilin
dc.date.accessioned2017-12-27T21:18:28Z
dc.date.available2017-12-27T21:18:28Z
dc.date.created2017-12-27
dc.identifier.urihttp://hdl.handle.net/10776/13034
dc.description.abstractIn 2013, George Church and his colleagues at Harvard University in Cambridge, Massachusetts published RNA-Guided Human Genome Engineering via Cas 9, in which they detailed their use of RNA-guided Cas 9 to genetically modify genes in human cells. Researchers use RNA-guided Cas 9 technology to modify the genetic information of organisms, DNA, by targeting specific sequences of DNA and subsequently replacing those targeted sequences with different DNA sequences. Church and his team used RNA-guided Cas 9 technology to edit the genetic information in human cells. Church and his colleagues also created a database that identified 190,000 unique guide RNAs for targeting almost half of the human genome that codes for proteins. In RNA-Guided Human Genome Engineering via Cas 9, the authors demonstrated that RNA-guided Cas 9 was a robust and simple tool for genetic engineering, which has enabled scientists to more easily manipulate genomes for the study of biological processes and genetic diseases.en_US
dc.format.mediumtext/xhtmlen_US
dc.language.isoen_USen_US
dc.language.isoen_USen_US
dc.publisherArizona State University. School of Life Sciences. Center for Biology and Society. Embryo Project Encyclopedia.en_US
dc.relation.ispartofEmbryo Project Encyclopediaen_US
dc.rightsCopyright Arizona Board of Regentsen_US
dc.subjectLiteratureen_US
dc.subject.lcshDiCarlo, James A.en_US
dc.subject.lcshHarvard Medical Schoolen_US
dc.subject.lcshChurch, George M. (George McDonald)en_US
dc.subject.lcshMali, Prashanten_US
dc.subject.lcshDoudna, Jennifer A.en_US
dc.subject.lcshCharpentier, Emmanuelleen_US
dc.subject.lcshGene Editingen_US
dc.subject.meshTranscription Activator-Like Effector Nucleasesen_US
dc.subject.meshscFV green fluorescent protein, recombinanten_US
dc.subject.meshClustered Regularly Interspaced Short Palindromic Repeatsen_US
dc.subject.meshCRISPR-Cas Systemsen_US
dc.subject.meshDNA End-Joining Repairen_US
dc.title"RNA-Guided Human Genome Engineering via Cas 9" (2013), by Prashant Mali, Luhan Yang, Kevin M. Esvelt, John Aach, Marc Guell, James E. DiCarlo, Julie E. Norville, and George M. Churchen_US
dc.typeArticleen_US
dc.typeTexten_US
dc.rights.licenseLicensed as Creative Commons Attribution-NonCommercial-Share Alike 3.0 Unported (CC BY-NC-SA 3.0) http://creativecommons.org/licenses/by-nc-sa/3.0/en_US
dc.subject.embryoPublicationsen_US
dc.description.typeArticlesen_US
dc.date.createdstandard2017-12-27en_US


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