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Dandy-Walker Syndrome is a congenital brain defect in humans characterized by malformations to the cerebellum, the part of the brain that controls movement, and to the ventricles, the fluid-filled cavities that surround the cerebellum. The syndrome is named for physicians Walter Dandy and Arthur Walker who described associated signs and symptoms of the syndrome in the 1900s. The malformations often develop during embryonic stages. In early infancy, symptoms include slow motor development and a progressive enlargement of the skull due to cerebrospinal fluid accumulation called hydrocephalus. The prognosis of Dandy-Walker syndrome is highly variable, ranging from minor or negligible birth defects to profound malformations, disability, or early death.