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dc.contributor.editorRoss, Christian H.en_US
dc.creatorGarcia, Dasia
dc.date.accessioned2017-02-16T16:16:18Z
dc.date.available2017-02-16T16:16:18Z
dc.date.created2017-02-16
dc.identifier.urihttp://hdl.handle.net/10776/11417
dc.description.abstractIn 2003, molecular biology and genetics researchers Coleen T. Murphy, Steven A. McCarroll, Cornelia I. Bargmann, Andrew Fraser, Ravi S. Kamath, Julie Ahringer, Hao Li, and Cynthia Kenyon conducted an experiment that investigated the cellular aging in, Caenorhabditis elegans (C. elegans) nematodes. The researchers investigated the interactions between the transcription factor DAF-16 and the genes that regulate the production of an insulin-like growth factor 1 (IGF-1-like) protein related to the development, reproduction, and aging in C. elegans. Transcription factors, like DAF-16, are proteins that regulate the transcription of deoxyribonucleic acid (DNA) into messenger ribonucleic acid (mRNA), which later determines which proteins the cell produces. The research team's experiment suggested that an increase in the activity of the DAF-16 protein decreases the transcription of the genes that regulate the production of IGF-1-like proteins, increasing lifespan in nematodes. The team published their results in the article 'Genes that act downstream of DAF-16 to influence the lifespan of Caenorhabditis elegans' in Nature in June 2003. By comparing the regulation of gene expression in C. elegans with similar genes and pathways in humans, Murphy's research team sought to better understand cellular function and aging in humans.en_US
dc.format.mediumtext/xhtmlen_US
dc.language.isoen_USen_US
dc.publisherArizona State University. School of Life Sciences. Center for Biology and Society. Embryo Project Encyclopedia.en_US
dc.relation.ispartofEmbryo Project Encyclopediaen_US
dc.rightsCopyright Arizona Board of Regentsen_US
dc.subjectExperimenten_US
dc.subject.lcshCaenorhabditis elegansen_US
dc.subject.lcshCaenorhabditisen_US
dc.subject.lcshInsulin-like growth factor-binding proteinsen_US
dc.subject.lcshIGF-binding proteinsen_US
dc.subject.lcshGenetic regulationen_US
dc.subject.lcshGene expressionen_US
dc.subject.meshdaf-16 protein, C elegansen_US
dc.subject.meshDAF-2 protein, C elegansen_US
dc.subject.meshIns-7 protein, C elegansen_US
dc.subject.meshRNA Interferenceen_US
dc.titleThe Effects of Gene Regulation on Aging in Caenorhabditis elegans (2003)en_US
dc.typeTexten_US
dc.rights.licenseLicensed as Creative Commons Attribution-NonCommercial-Share Alike 3.0 Unported (CC BY-NC-SA 3.0) http://creativecommons.org/licenses/by-nc-sa/3.0/en_US
dc.subject.embryoExperimentsen_US
dc.subject.tagGene Regulationen_US
dc.subject.tagC. elegansen_US
dc.subject.tagAgeingen_US
dc.description.typeArticlesen_US
dc.date.createdstandard2017-02-16en_US


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