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dc.contributor.editorTurriziani Colonna, Federicaen_US
dc.creatorBartlett, Zane
dc.creatorYang, Joannaen_US
dc.date.accessioned2017-02-07T17:48:27Z
dc.date.available2017-02-07T17:48:27Z
dc.date.created2017-02-07
dc.identifier.urihttp://hdl.handle.net/10776/11402
dc.description.abstractTelomeres are structures at the ends of DNA strands that get longer in the DNA of sperm cells as males age. That phenomenon is different for most other types of cells, for which telomeres get shorter as organisms age. In 1992, scientists showed that telomere length (TL) in sperm increases with age in contrast to most cell of most other types. Telomeres are the protective caps at the end of DNA strands that preserve chromosomal integrity and contribute to DNA length and stability. In most cells, telomeres shorten with each cell division due to incomplete replication, though the enzyme telomerase functions in some cell lines that undergo repetitive divisions to replenish any lost length and to prevent degradation. Cells, and therefore organisms, with short telomeres are more susceptible to mutations and genetic diseases. While TL increases in a subset of sperm cells and longer telomeres may prevent early disintegration of DNA, it may also prevent natural mechanisms of apoptosis, or cell death, from occurring in abnormal sperm.en_US
dc.format.mediumtext/xhtmlen_US
dc.language.isoen_USen_US
dc.publisherArizona State University. School of Life Sciences. Center for Biology and Society.en_US
dc.relation.ispartofEmbryo Project Encyclopediaen_US
dc.rightsCopyright Arizona Board of Regentsen_US
dc.subjectConcepten_US
dc.subject.lcshTelomereen_US
dc.subject.lcshAgingen_US
dc.subject.lcshSpermen_US
dc.subject.lcshSpermatozoaen_US
dc.subject.lcshTelomeraseen_US
dc.subject.lcshBlackburn, Elizabeth H.en_US
dc.subject.lcshGreider, Carol W.en_US
dc.subject.lcshSzostak, Jack W.en_US
dc.subject.lcshSidney Farber Cancer Instituteen_US
dc.subject.lcshHarvard Medical Schoolen_US
dc.subject.lcshUniversity of California, Berkeleyen_US
dc.subject.meshTelomereen_US
dc.titlePaternal Sperm Telomere Elongation and Its Impact on Offspring Fitnessen_US
dc.typeTexten_US
dc.rights.licenseLicensed as Creative Commons Attribution-NonCommercial-Share Alike 3.0 Unported (CC BY-NC-SA 3.0) http://creativecommons.org/licenses/by-nc-sa/3.0/en_US
dc.subject.embryoTheoriesen_US
dc.description.typeArticlesen_US
dc.date.createdstandard2017-02-07en_US


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